Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Chloro-1-methylpiperidine

  • CAS No. 5570-77-4

  • Cat. No. CS-W013387
  • Purity≥97%
  • MDL No.MFCD00044489

*For research and further manufacturing use only, not for direct human use.

4-Chloro-1-methylpiperidine|CS-W013387

Structure of 5570-77-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 5570-77-4
  • Cat. No. CS-W013387
  • Purity ≥97%
  • MDL No. MFCD00044489
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClN
  • Molecular Weight 133.62
  • Synonym(s) Piperidine, 4-chloro-1-methyl-; 4-Chloro-1-methylpiperidine
  • SMILES CN1CCC(CC1)Cl

Description

4-Chloro-1-methylpiperidine is a sterically hindered, bench-stable piperidine derivative featuring a chlorine atom at the 4-position and a methyl group on nitrogen. This combination imparts enhanced metabolic stability and favorable lipophilicity, making it a valuable scaffold in medicinal chemistry for optimizing pharmacokinetic profiles.

Application

4-Chloro-1-methylpiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through nucleophilic substitution and coupling reactions. Its chloro group at the 4-position provides high reactivity for C–N bond formation, while the N-methyl functionality enhances lipophilicity and metabolic stability. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, facilitating efficient functionalization in API development workflows.

Synthesis

  • Route1
    • In-stock
      N-Methylvalerolactam|CS-0222604
      931-20-4
    • null|null
      103057-10-9
    • ~52%
    • In-stock
      4-Chloro-1-methylpiperidine|CS-W013387
      5570-77-4

    References

    • Schering Corporation Patent: US5807872 A1, 1998 ;
  • Route2
    • 1-Methyl-4-chloropiperidine hydrochloride|CS-W016031
      5382-23-0
    • ~%
    • In-stock
      4-Chloro-1-methylpiperidine|CS-W013387
      5570-77-4

    References

    • WO2005/3131 A1, ; Page 58 ; WO 2005/003131 A1
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 70, p. 1826

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3 (8)
Packing Group : Ⅲ
Hazard Statements : H226-H314-H412
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P273-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   3.24
  • LogP   1.3194
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Chloro-1-methylpiperidine sigma4-Chloro-1-methylpiperidine manufacturer4-Chloro-1-methylpiperidine price4-Chloro-1-methylpiperidine structure4-Chloro-1-methylpiperidine SDSbuy 4-Chloro-1-methylpiperidine4-Chloro-1-methylpiperidine supplier4-Chloro-1-methylpiperidine uses4-Chloro-1-methylpiperidine molecular weightprice of 4-Chloro-1-methylpiperidine4-Chloro-1-methylpiperidine chemical name formula of 4-Chloro-1-methylpiperidine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label