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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-chloropiperidine-1-carboxylate

  • CAS No. 154874-94-9

  • Cat. No. CS-W001453
  • Purity≥95%
  • MDL No.MFCD04115040

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-chloropiperidine-1-carboxylate|CS-W001453

Structure of 154874-94-9

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General Information

  • CAS No. 154874-94-9
  • Cat. No. CS-W001453
  • Purity ≥95%
  • MDL No. MFCD04115040
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈ClNO₂
  • Molecular Weight 219.71
  • Synonym(s) N-BOC-4-CHLORO-PIPERIDINE
  • SMILES ClC1CCN(CC1)C(=O)OC(C)(C)C

Description

2-Chlorobenzaldehyde has been used in generation of small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and thioureas

Application

tert-Butyl 4-chloropiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to chlorinated piperidine scaffolds. The tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the 4-chloro substituent offers a reactive handle for palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with diverse functional groups make it ideal for multi-step synthesis and late-stage derivatization in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   2.6247
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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