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CS-W001157 4
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Methyl 2-hydroxynicotinate

  • CAS No. 67383-31-7

  • Cat. No. CS-0097361
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-hydroxynicotinate|CS-0097361

Structure of 67383-31-7

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General Information

  • CAS No. 67383-31-7
  • Cat. No. CS-0097361
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 2-Hydroxy-3-pyridinecarboxylic acid methyl ester
  • SMILES O=C(C1=CC=CN=C1O)OC

Description

Methyl 2-hydroxynicotinate is a bench-stable, moisture-tolerant ester featuring a strategically positioned hydroxyl group ortho to the pyridine nitrogen. This functionalization enables direct participation in cross-coupling and cyclization cascades, delivering access to bioactive heterocycles with enhanced solubility profiles under standard conditions.

Application

Methyl 2-hydroxynicotinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to pyridine-based heterocycles and bioactive scaffolds. Its dual functionality—phenolic hydroxyl and ester group—facilitates selective derivatization, including etherification, acylation, and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and is readily purified by standard techniques, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.5738
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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