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CS-W001157 4
Total: USD 88.00

2-Methoxynicotinic acid

  • CAS No. 16498-81-0

  • Cat. No. CS-W019566
  • Purity≥98%
  • MDL No.MFCD00085110

*For research and further manufacturing use only, not for direct human use.

2-Methoxynicotinic acid|CS-W019566

Structure of 16498-81-0

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General Information

  • CAS No. 16498-81-0
  • Cat. No. CS-W019566
  • Purity ≥98%
  • MDL No. MFCD00085110
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight None
  • Synonym(s) 6-methoxypyridine-3-carboxylic acid; 2-Methoxynicotinic acid
  • SMILES O=C(O)C1=C(OC)N=CC=C1

Description

2-Methoxynicotinic acid is a bench-stable, moisture-tolerant heterocyclic carboxylic acid featuring a methoxy group at the 2-position of the pyridine ring. This electronic and steric configuration enhances solubility in polar organic solvents and facilitates direct incorporation into pharmaceutical intermediates, coupling reactions, and bioactive molecule scaffolds without requiring protection or derivatization.

Application

2-Methoxynicotinic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted nicotinamide derivatives and heterocyclic scaffolds. Its methoxy group enhances solubility and modulates electronic properties, while the carboxylic acid functionality facilitates direct coupling reactions or derivatization under standard conditions. The compound exhibits good bench stability and is compatible with common functional group transformations, making it a practical choice for synthesizing bioactive molecules and API intermediates.

Synthesis

  • Route1

    References

    • US4342771 A1, ;
  • Route2

    References

    • WO2011/8247 A1, ; Page/Page column 215-216 ;
  • Route3
    • In-stock
      2-Chloronicotinic acid|CS-W017965
      2942-59-8
    • null|null
      124-41-4
    • ~64%
    • In-stock
      2-Methoxynicotinic acid|CS-W019566
      16498-81-0

    References

    • Elliott, Mark L.; Goddard, Carl J. Synthetic Communications, 1989 , vol. 19, # 9-10 p. 1505 - 1508

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P264-P280-P305+P351+P338-P337+P313

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7884
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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