Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-(Trifluoromethyl)benzenesulfonamide

  • CAS No. 672-58-2

  • Cat. No. CS-W013044
  • Purity≥98%
  • MDL No.MFCD00042421

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethyl)benzenesulfonamide|CS-W013044

Structure of 672-58-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 672-58-2
  • Cat. No. CS-W013044
  • Purity ≥98%
  • MDL No. MFCD00042421
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃NO₂S
  • Molecular Weight 225.19
  • Synonym(s) α,α,α-Trifluorotoluene-3-sulfonamide
  • SMILES O=S(C1=CC=CC(C(F)(F)F)=C1)(N)=O

Description

3-(Trifluoromethyl)benzenesulfonamide features a strongly electron-withdrawing trifluoromethyl group positioned ortho to the sulfonamide, enhancing its acidity and metabolic stability. This combination imparts robust solubility in polar organic solvents and resistance to hydrolytic degradation. The molecule serves as a key scaffold in medicinal chemistry for kinase inhibitors and enzyme modulators due to its ability to form strong hydrogen bonds and occupy hydrophobic pockets.

Application

3-(Trifluoromethyl)benzenesulfonamide serves as a robust sulfonamide building block in medicinal chemistry, offering enhanced metabolic stability and lipophilicity due to the electron-withdrawing trifluoromethyl group. It functions effectively in amide coupling, nucleophilic substitution, and transition-metal-catalyzed cross-coupling reactions, with good bench stability and ease of purification. Widely employed in the synthesis of kinase inhibitors and other bioactive heterocycles, it enables efficient access to complex scaffolds under standard reaction conditions.

Synthesis

  • Route1

    References

    • Zhurnal Obshchei Khimii, , vol. 29, p. 553,555; engl.Ausg.S.549,551
  • Route2
    • null|null
      98-16-8
    • ~%
    • In-stock
      3-(Trifluoromethyl)benzenesulfonamide|CS-W013044
      672-58-2

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 49, # 5 p. 1182 - 1192
  • Route3
    • null|null
      17113-81-4
    • ~%
    • In-stock
      3-(Trifluoromethyl)benzenesulfonamide|CS-W013044
      672-58-2

    References

    • Chemische Berichte, , vol. 124, # 9 p. 1997 - 2000

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   60.16
  • LogP   1.3528
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3-(Trifluoromethyl)benzenesulfonamide sigma3-(Trifluoromethyl)benzenesulfonamide manufacturer3-(Trifluoromethyl)benzenesulfonamide price3-(Trifluoromethyl)benzenesulfonamide structure3-(Trifluoromethyl)benzenesulfonamide SDSbuy 3-(Trifluoromethyl)benzenesulfonamide3-(Trifluoromethyl)benzenesulfonamide supplier3-(Trifluoromethyl)benzenesulfonamide uses3-(Trifluoromethyl)benzenesulfonamide molecular weightprice of 3-(Trifluoromethyl)benzenesulfonamide3-(Trifluoromethyl)benzenesulfonamide chemical name formula of 3-(Trifluoromethyl)benzenesulfonamide
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label