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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethyl)benzenesulfonamide

  • CAS No. 830-43-3

  • Cat. No. CS-0097815
  • Purity≥98%
  • MDL No.MFCD00159251

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethyl)benzenesulfonamide|CS-0097815

Structure of 830-43-3

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General Information

  • CAS No. 830-43-3
  • Cat. No. CS-0097815
  • Purity ≥98%
  • MDL No. MFCD00159251
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃NO₂S
  • Molecular Weight 225.19
  • Synonym(s) α,α,α-Trifluorotoluene-4-sulfonamide
  • SMILES O=S(C1=CC=C(C=C1)C(F)(F)F)(N)=O

Description

4-(Trifluoromethyl)benzenesulfonamide features a strongly electron-deficient aryl ring flanked by a sulfonamide group, enabling robust hydrogen bonding and enhanced solubility in polar solvents. This combination delivers high stability under standard bench conditions, facilitating its use in medicinal chemistry and as a building block for bioactive compounds.

Application

4-(Trifluoromethyl)benzenesulfonamide serves as a robust sulfonamide building block in medicinal chemistry, enabling efficient construction of biologically active scaffolds. Its trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the sulfonamide moiety provides strong hydrogen-bonding capacity and favorable pharmacokinetic properties. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, facilitating straightforward purification and integration into diverse synthetic sequences.

Synthesis

  • Route1

    References

    • Liebigs Annales, , # 1 p. 141 - 154
  • Route2
    • 4-(Trifluoromethyl)aniline Leflunomide Impurity|CS-0229655
      455-14-1
    • ~%
    • In-stock
      4-(Trifluoromethyl)benzenesulfonamide|CS-0097815
      830-43-3

    References

    • Liebigs Annales, , # 1 p. 141 - 154

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   1.3528
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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