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CS-W001157 4
Total: USD 88.00

Phenylmethanesulfonamide

  • CAS No. 4563-33-1

  • Cat. No. CS-W005788
  • Purity≥98%
  • MDL No.MFCD00041893

*For research and further manufacturing use only, not for direct human use.

Phenylmethanesulfonamide|CS-W005788

Structure of 4563-33-1

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General Information

  • CAS No. 4563-33-1
  • Cat. No. CS-W005788
  • Purity ≥98%
  • MDL No. MFCD00041893
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₂S
  • Molecular Weight 171.22
  • Synonym(s) Benzylsulfonamide
  • SMILES NS(CC1=CC=CC=C1)(=O)=O

Description

Phenylmethanesulfonamide delivers a robust sulfonamide functionality appended to a benzyl scaffold, enabling direct incorporation into bioactive molecule design. This bench-stable derivative features a polar yet lipophilic profile, facilitating solubility in common organic solvents and compatibility with diverse synthetic transformations.

Application

Phenylmethanesulfonamide serves as a stable, bench-ready sulfonamide source for amide bond formation and nitrogen transfer reactions. Its arylsulfonyl group enhances functional group tolerance and facilitates purification via crystallization or chromatography. Widely employed in medicinal chemistry, it functions as a key building block for sulfonamide-containing heterocycles and protein-targeting scaffolds, enabling efficient access to bioactive molecules through established coupling protocols.

Synthesis

  • Route1
    • null|null
      100-53-8
    • ~98%
    • In-stock
      Phenylmethanesulfonamide|CS-W005788
      4563-33-1

    References

    • Bahrami, Kiumars; Khodaei, Mohammad M.; Soheilizad, Mehdi Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4843 - 4846
  • Route2
    • null|null
      85952-14-3
    • ~80%
    • In-stock
      Phenylmethanesulfonamide|CS-W005788
      4563-33-1

    References

    • Moroda, Atsushi; Togo, Hideo Tetrahedron, 2006 , vol. 62, # 52 p. 12408 - 12414
  • Route3

    References

    • Bahrami, Kiumars; Khodaei, Mohammad M.; Soheilizad, Mehdi Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4843 - 4846

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   0.4751
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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