Hydroxy-PEG1-(CH2)2-Boc

Name: Hydroxy-PEG1-(CH2)2-Boc
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 671802-00-9
Cat. No. CS-0047718
Purity≥96%
MDL No.MFCD22056310

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 671802-00-9
Cat. No. CS-0047718
Purity ≥96%
MDL No. MFCD22056310
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₈O₄
Molecular Weight 190.24
Synonym(s) None
SMILES O=C(OC(C)(C)C)CCOCCO

Description

Hydroxy-PEG1-(CH2)2-Boc features a hydroxyl-terminated PEG chain linked to a Boc-protected amine via a two-carbon spacer. This functionalized intermediate enables controlled conjugation and protection in peptide synthesis, offering enhanced solubility and stability under standard conditions.

Application

Hydroxy-PEG1-(CH2)2-Boc serves as a versatile bifunctional building block for conjugation and protection strategies in synthetic chemistry. The terminal hydroxyl group enables facile derivatization, while the Boc-protected amine facilitates selective coupling reactions under mild conditions. Its PEG1 spacer provides enhanced solubility and stability, supporting efficient purification and integration into complex molecular architectures.

Synthesis

Route1
- 1663-39-4
- In-stock
  
  107-21-1
- ~24%
- In-stock
  
  671802-00-9
References
- AMBRX, INC.; BARNETT, Richard S.; TIAN, Feng; PUTNAM, Anna-maria A. Hays; GYMNOPOULOS, Marco; KNUDSEN, Nick; BECK, Andrew; SUN, Ying Patent: WO2013/185117 A1, 2013 ; Location in patent: Paragraph 00476 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 55.76
LogP 0.7271
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 5

Other Classifications

Life Science Linker Hydroxy PEG

Building Blocks Skeleton Fatty chain compounds

Building Blocks Functional Group Boc

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Ester

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Key Words

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Hydroxy-PEG1-(CH2)2-Boc

CAS No. 671802-00-9

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