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Structure of 66417-73-0
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1-Acetyl-3-bromoindole features a bromine substituent at the 3-position and an acetyl group at the 1-position of the indole core, combining electrophilic reactivity with enhanced solubility. This configuration enables direct incorporation into C–H functionalization cascades and transition-metal-catalyzed cross-couplings under mild conditions. The molecule exhibits bench-stable handling characteristics and compatibility with diverse reaction media.
1-Acetyl-3-bromoindole serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the 3-position via palladium-catalyzed cross-coupling. The acetyl group enhances solubility and stabilizes the indole core against overreaction, while the bromo substituent provides high reactivity in standard coupling protocols. Its bench-stable crystalline form facilitates handling and purification, making it ideal for medicinal chemistry campaigns requiring rapid diversification of indole scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: