Lot numbers can be found on the outside label of a product:
2,4,7-trichloroquinazoline
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CAS No. 6625-94-1
- Cat. No. CS-W001031
- Purity≥95%
- MDL No.MFCD09954887
*For research and further manufacturing use only, not for direct human use.
Structure of 6625-94-1
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General Information
- CAS No. 6625-94-1
- Cat. No. CS-W001031
- Purity ≥95%
- MDL No. MFCD09954887
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₃Cl₃N₂
- Molecular Weight 233.48
- Synonym(s) 2,4-Dichloro-7-chloroquinazoline
- SMILES Clc1ccc2c(Cl)nc(Cl)nc2c1
Description
2,4,7-Trichloroquinazoline features a highly electron-deficient quinazoline core with three chlorine substituents positioned to enhance reactivity in nucleophilic substitution processes. This structural configuration enables efficient coupling with diverse amines and heterocycles, making it a valuable scaffold for medicinal chemistry applications. The molecule exhibits robust stability under standard bench conditions and facilitates rapid derivatization without requiring harsh activation protocols.
Application
2,4,7-Trichloroquinazoline serves as a versatile building block for the synthesis of biologically active heterocycles, enabling efficient construction of quinazoline-based scaffolds. Its three chlorine substituents provide orthogonal reactivity for nucleophilic substitution, facilitating the introduction of diverse aryl, alkyl, and amino groups under mild conditions. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it ideal for medicinal chemistry campaigns and process-scale applications.
Synthesis
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Route1
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In-stock
13165-35-0 - ~99%
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In-stock
6625-94-1
References
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Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
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Route2
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89-77-0 - ~%
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In-stock
6625-94-1
References
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Pharmaceutical Chemistry Journal, , vol. 21, # 7 p. 478 - 483 Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 7 p. 802 - 807
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Route3
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214288-97-8 - ~%
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In-stock
6625-94-1
References
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Journal of the Chemical Society, , p. 1759,1765
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 25.78
- LogP 3.59
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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