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CS-W001157 4
Total: USD 88.00

(6-Chloropyridin-2-yl)boronic acid

  • CAS No. 652148-90-8

  • Cat. No. CS-0109632
  • Purity≥95%
  • MDL No.MFCD08063028

*For research and further manufacturing use only, not for direct human use.

(6-Chloropyridin-2-yl)boronic acid|CS-0109632

Structure of 652148-90-8

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General Information

  • CAS No. 652148-90-8
  • Cat. No. CS-0109632
  • Purity ≥95%
  • MDL No. MFCD08063028
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BClNO₂
  • Molecular Weight None
  • Synonym(s) boronic acid, B-(6-chloro-2-pyridinyl)-
  • SMILES OB(C1=NC(Cl)=CC=C1)O

Description

This boronate moiety features a chlorine-substituted pyridine ring, enabling direct functionalization in cross-coupling reactions. The electron-deficient heterocycle enhances reactivity in palladium-catalyzed processes, delivering diverse N-heteroaryl architectures under standard conditions.

Application

(6-Chloropyridin-2-yl)boronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. Its chlorine substituent provides orthogonal reactivity for downstream functionalization, while the boronic acid moiety offers excellent bench stability and compatibility with diverse reaction partners. This compound facilitates the construction of biaryl scaffolds and complex heterocyclic systems commonly found in pharmaceutical intermediates and agrochemicals.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.5852
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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