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CS-W001157 4
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(3-Chloropyridin-2-yl)boronic acid

  • CAS No. 1448866-17-8

  • Cat. No. CS-0162304
  • Purity≥95%
  • MDL No.MFCD12401037

*For research and further manufacturing use only, not for direct human use.

(3-Chloropyridin-2-yl)boronic acid|CS-0162304

Structure of 1448866-17-8

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General Information

  • CAS No. 1448866-17-8
  • Cat. No. CS-0162304
  • Purity ≥95%
  • MDL No. MFCD12401037
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BClNO₂
  • Molecular Weight 157.36
  • Synonym(s) (3-Chloro-2-pyridinyl)boronic acid
  • SMILES ClC1=CC=CN=C1B(O)O

Description

This boronate moiety features a chlorinated pyridine scaffold enabling direct functionalization in cross-coupling reactions. The electron-deficient heterocycle enhances reactivity under standard conditions, while the bench-stable boronic acid group facilitates handling and integration into synthetic sequences.

Application

(3-Chloropyridin-2-yl)boronic acid serves as a versatile building block in cross-coupling reactions, enabling efficient C–C bond formation under palladium catalysis. Its pyridine scaffold offers enhanced solubility and stability compared to related arylboron reagents, while the ortho-chloro substituent provides a handle for downstream functionalization via nucleophilic substitution or further coupling. The compound exhibits excellent bench stability, facilitates straightforward purification by crystallization, and functions reliably in Suzuki-Miyaura protocols across diverse substrates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.5852
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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