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CS-W001157 4
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Imidazo[1,2-a]pyrimidine-3-carboxylic acid

  • CAS No. 64951-11-7

  • Cat. No. CS-W022759
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD09994697

*For research and further manufacturing use only, not for direct human use.

Imidazo[1,2-a]pyrimidine-3-carboxylic acid|CS-W022759

Structure of 64951-11-7

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General Information

  • CAS No. 64951-11-7
  • Cat. No. CS-W022759
  • Purity ≥95%
  • MDL No. MFCD09994697
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O₂
  • Molecular Weight None
  • Synonym(s) Imidazo[1,2-a]pyrimidine-3-carboxylicaci
  • SMILES O=C(C1=CN=C2N=CC=CN21)O

Description

Imidazo[1,2-a]pyrimidine-3-carboxylic acid features a rigid heteroaromatic core with a carboxylic acid group at the 3-position, enabling direct conjugation in medicinal chemistry. This scaffold delivers enhanced metabolic stability and favorable solubility profiles, making it a valuable building block for targeted kinase inhibitors and CNS-penetrant drug candidates.

Application

Imidazo[1,2-a]pyrimidine-3-carboxylic acid serves as a versatile scaffold for medicinal chemistry and materials science applications. Its fused heterocyclic core exhibits enhanced metabolic stability and favorable physicochemical properties. The carboxylic acid functionality enables direct derivatization via amide coupling, esterification, or activation for cross-coupling reactions. Bench-stable and readily purified by recrystallization, it functions as a key building block in the synthesis of kinase inhibitors and functionalized aromatic systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.49
  • LogP   0.4275
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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