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CS-W001157 4
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3-(2-Hydroxyethyl)benzeneboronic acid

  • CAS No. 647853-32-5

  • Cat. No. CS-0139539
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(2-Hydroxyethyl)benzeneboronic acid|CS-0139539

Structure of 647853-32-5

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General Information

  • CAS No. 647853-32-5
  • Cat. No. CS-0139539
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BO₃
  • Molecular Weight 165.98
  • Synonym(s) (3-(2-Hydroxyethyl)phenyl)boronic acid
  • SMILES OB(C1=CC=CC(CCO)=C1)O

Description

3-(2-Hydroxyethyl)benzeneboronic acid features a boronic acid group conjugated to a phenyl ring via a hydroxyethyl linker, enabling robust coupling in Suzuki-Miyaura reactions. The pendant hydroxyl enhances solubility in aqueous and polar organic media, while the boronate moiety remains stable under standard bench conditions. This structure facilitates efficient incorporation into complex molecular architectures with minimal purification burden.

Application

3-(2-Hydroxyethyl)benzeneboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, offering reliable coupling efficiency with aryl halides and triflates. The pendant hydroxyl group enables facile derivatization and enhances solubility, while the boronic acid functionality exhibits good bench stability and compatibility with diverse reaction conditions. Its structure facilitates incorporation into bioactive scaffolds and functional materials.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.0988
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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