Lot numbers can be found on the outside label of a product:
Boc-N-Me-Tyr(Bzl)-OH
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CAS No. 64263-81-6
- Cat. No. CS-W011749
- Purity≥98%
- MDL No.MFCD00038755
*For research and further manufacturing use only, not for direct human use.
Structure of 64263-81-6
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General Information
- CAS No. 64263-81-6
- Cat. No. CS-W011749
- Purity ≥98%
- MDL No. MFCD00038755
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₂H₂₇NO₅
- Molecular Weight 385.46
- Synonym(s) None
- SMILES O=C(O)[C@@H](N(C(OC(C)(C)C)=O)C)CC1=CC=C(OCC2=CC=CC=C2)C=C1
Description
Boc-N-Me-Tyr(Bzl)-OH is a protected tyrosine derivative featuring a tert-butoxycarbonyl group on the amine and a benzyl ether on the phenolic hydroxyl. This dual protection enables stable incorporation into peptide synthesis workflows, where the Boc group facilitates orthogonal deprotection. The benzyl-protected hydroxyl resists premature oxidation, enhancing handling reliability in complex sequences.
Application
Boc-N-Me-Tyr(Bzl)-OH serves as a versatile building block for peptide synthesis, enabling the incorporation of N-methylated tyrosine residues with orthogonal protection. The Boc group provides stable N-terminal protection, while the benzyl ether protects the phenolic hydroxyl, allowing selective deprotection and functionalization. This derivative facilitates efficient coupling reactions and is compatible with standard Fmoc-based workflows, offering robust bench stability and ease of purification in complex sequence assembly.
Synthesis
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Route1
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In-stock
2130-96-3 -
74-88-4 - ~98%
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In-stock
64263-81-6
References
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Bates, Robert B.; Gin, Susan L.; Hassen, Mark A.; Hruby, Victor J.; Janda, Kim D.; et al. Heterocycles, 1984 , vol. 22, # 4 p. 785 - 790
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Route2
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In-stock
2130-96-3
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74-88-4
- ~%
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In-stock
64263-81-6
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138774-98-8
References
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Journal of Organic Chemistry, , vol. 62, # 7 p. 2054 - 2069
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Route3
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In-stock
63769-58-4 -
74-88-4
- ~%
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In-stock
64263-81-6
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138774-98-8
References
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Journal of Organic Chemistry, , vol. 62, # 7 p. 2054 - 2069
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Safety Information
Download SDS|
GHS Pictogram :
N/A
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GHS No : N/A
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Signal Word : N/A
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : N/A
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Precautionary Statements : N/A
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Quality Control
Computational Chemistry Data
- TPSA 76.07
- LogP 4.1282
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 7
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Key Words
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