2′-Deoxy-2′-fluoroadenosine

Name: 2′-Deoxy-2′-fluoroadenosine
Brand: ChemScene
Availability: InStock
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CAS No. 64183-27-3
Cat. No. CS-0097284
Purity≥97%
MDL No.MFCD09750859

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 64183-27-3

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General Information

CAS No. 64183-27-3
Cat. No. CS-0097284
Purity ≥97%
MDL No. MFCD09750859
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂FN₅O₃
Molecular Weight 269.24
Synonym(s) None
SMILES OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(N=CN=C3N)=C3N=C2)O1

Description

2′-Deoxy-2′-fluoroadenosine is a synthetic nucleoside analog featuring a fluorine atom at the 2′ position of the ribose ring, enhancing metabolic stability and resistance to enzymatic degradation. This modification improves its utility in probing RNA processing pathways and developing antiviral therapeutics.

Application

2′-Deoxy-2′-fluoroadenosine serves as a valuable nucleoside analog in medicinal chemistry, where the 2′-fluoro substitution enhances metabolic stability and resistance to enzymatic degradation. It functions as a key building block for antiviral and anticancer research, enabling efficient incorporation into oligonucleotides and facilitating studies on RNA polymerase inhibition. The fluorine atom provides favorable electronic effects without significant steric perturbation, supporting robust coupling reactions and reliable synthesis of modified nucleic acid constructs.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 119.31
LogP -1.0028
H_Acceptors 8
H_Donors 3
Rotatable_Bonds 2

Other Classifications

Life Science Nucleosides & Nucleotides Other Protective Nucleosides

Chemical Biology Nucleic Acid Chemistry Protected Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

Key Words

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2′-Deoxy-2′-fluoroadenosine

CAS No. 64183-27-3

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