Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

tert-Butyl (4-bromophenyl)(methyl)carbamate

  • CAS No. 639520-70-0

  • Cat. No. CS-0187654
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (4-bromophenyl)(methyl)carbamate|CS-0187654

Structure of 639520-70-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 639520-70-0
  • Cat. No. CS-0187654
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆BrNO₂
  • Molecular Weight 286.16
  • Synonym(s) tert-Butyl N-(4-bromophenyl)-N-methylcarbamate
  • SMILES CC(C)(C)OC(=O)N(C)C1=CC=C(C=C1)Br

Description

tert-Butyl (4-bromophenyl)(methyl)carbamate features a brominated aromatic ring paired with a sterically hindered tert-butyl carbamate group, enabling stable protection of primary amines. The methyl substitution enhances electronic tuning, while the para-bromo handle facilitates downstream coupling reactions in medicinal chemistry and materials synthesis.

Application

tert-Butyl (4-bromophenyl)(methyl)carbamate serves as a stable, bench-ready building block for the synthesis of biaryl and heterocyclic scaffolds. The bromo group enables palladium-catalyzed cross-coupling reactions such as Suzuki and Buchwald–Hartwig transformations, while the carbamate functionality provides orthogonal protection for nitrogen. Its methyl substitution enhances solubility and reduces aggregation during purification, facilitating efficient downstream functionalization in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • In-stock
      tert-Butyl (4-bromophenyl)carbamate|CS-0018928
      131818-17-2
    • null|null
      74-88-4
    • ~%
    • In-stock
      tert-Butyl (4-bromophenyl)(methyl)carbamate|CS-0187654
      639520-70-0

    References

    • ABBOTT LABORATORIES Patent: WO2004/869 A1, 2003 ; Location in patent: Page 22 ; WO 2004/000869 A1
  • Route2

    References

    • Malysheva, Yulia B.; Combes, Sebastien; Fedorov, Alexey Yu.; Knochel, Paul; Gavryushin, Andrei E. Synlett, 2012 , vol. 23, # 8 p. 1205 - 1208
  • Route3
    • null|null
      32857-49-1
    • ~%
    • In-stock
      tert-Butyl (4-bromophenyl)(methyl)carbamate|CS-0187654
      639520-70-0

    References

    • Yoshida, Suguru; Igawa, Kazunobu; Tomooka, Katsuhiko Journal of the American Chemical Society, 2012 , vol. 134, # 47 p. 19358 - 19361

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   29.54
  • LogP   3.8204
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 639520-70-0 sigma639520-70-0 manufacturer639520-70-0 price639520-70-0 structure639520-70-0 SDSbuy 639520-70-0639520-70-0 supplier639520-70-0 uses639520-70-0 molecular weightprice of 639520-70-0639520-70-0 chemical name formula of 639520-70-0
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label