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CS-W001157 4
Total: USD 88.00

4-Bromo-N-methylaniline

  • CAS No. 6911-87-1

  • Cat. No. CS-0038061
  • Purity≥95%
  • MDL No.MFCD03030391

*For research and further manufacturing use only, not for direct human use.

4-Bromo-N-methylaniline|CS-0038061

Structure of 6911-87-1

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General Information

  • CAS No. 6911-87-1
  • Cat. No. CS-0038061
  • Purity ≥95%
  • MDL No. MFCD03030391
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrN
  • Molecular Weight 186.05
  • Synonym(s) P-BROMO-N-METHYLANILINE
  • SMILES CNC1=CC=C(C=C1)Br

Description

4-Bromo-N-methylaniline is a brominated aniline derivative featuring a methyl group on the nitrogen, enhancing solubility and stability. This electron-rich arylamine integrates readily into cross-coupling reactions and serves as a key intermediate in pharmaceutical synthesis and agrochemical development.

Application

4-Bromo-N-methylaniline serves as a versatile building block in medicinal chemistry and materials synthesis, enabling palladium-catalyzed cross-coupling reactions due to its stable aryl bromide functionality and N-methylated aniline scaffold. Its bench-stable nature, compatibility with diverse reaction conditions, and tolerance of common functional groups facilitate efficient access to substituted biaryls and heterocyclic frameworks.

Synthesis

  • Route1
    • null|null
      100-61-8
    • ~10%
    • In-stock
      4-Bromo-N-methylaniline|CS-0038061
      6911-87-1

    References

    • Cho, Bongsup P.; Yang, Tianle; Blankenship, Lonnie R.; Moody, Joanna D.; Churchwell, Mona; Beland, Frederick A.; Culp, Sandra J. Chemical Research in Toxicology, 2003 , vol. 16, # 3 p. 285 - 294
  • Route2
    • null|null
      106-40-1
    • null|null
      74-88-4
    • ~26%
    • In-stock
      4-Bromo-N-methylaniline|CS-0038061
      6911-87-1
    • null|null
      586-77-6

    References

    • WO2011/130628 A1, ; Page/Page column 217 ; WO 2011/130628 A1
  • Route3
    • null|null
      67-56-1
    • null|null
      106-40-1
    • ~%
    • In-stock
      4-Bromo-N-methylaniline|CS-0038061
      6911-87-1

    References

    • Tetrahedron Letters, , vol. 48, # 19 p. 3367 - 3370

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.4908
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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