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CS-W001157 4
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6-chloro-5-methoxy-1H-indole

  • CAS No. 63762-72-1

  • Cat. No. CS-0036414
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-chloro-5-methoxy-1H-indole|CS-0036414

Structure of 63762-72-1

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General Information

  • CAS No. 63762-72-1
  • Cat. No. CS-0036414
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈ClNO
  • Molecular Weight 181.62
  • Synonym(s) 6-Chloro-5-methoxyindole
  • SMILES COC1=CC2=C(C=C1Cl)NC=C2

Description

6-Chloro-5-methoxy-1H-indole features a chlorinated and methoxy-substituted indole core, offering enhanced electron-withdrawing character and improved solubility in organic media. This bench-stable heterocycle integrates readily into synthetic routes for pharmaceutical intermediates, enabling efficient construction of complex nitrogen-containing architectures under standard conditions.

Application

6-Chloro-5-methoxy-1H-indole serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted indole scaffolds through palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its orthogonal functionalization profile—combining a reactive chloro group with a stable methoxy substituent—facilitates sequential derivatization in medicinal chemistry and materials science applications. The compound exhibits excellent bench stability and simplifies purification in multi-step syntheses.

Synthesis

  • Route1
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      1203844-49-8
    • ~%
    • In-stock
      6-chloro-5-methoxy-1H-indole|CS-0036414
      63762-72-1

    References

    • INTELLIKINE, INC.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; MARTIN, Michael; ROMMEL, Christian Patent: WO2010/6086 A2, 2010 ; Location in patent: Page/Page column 82-83 ; WO 2010/006086 A2
  • Route2
    • null|null
      615-74-7
    • ~%
    • In-stock
      6-chloro-5-methoxy-1H-indole|CS-0036414
      63762-72-1

    References

    • Batandier; Marsura; Luu-Duc Farmaco, Edizione Scientifica, 1987 , vol. 42, # 3 p. 227 - 230
  • Route3

    References

    • Batandier; Marsura; Luu-Duc Farmaco, Edizione Scientifica, 1987 , vol. 42, # 3 p. 227 - 230

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.02
  • LogP   2.8299
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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