(2S,5S)-5-Hydroxypiperidine-2-carboxylic acid

Name: (2S,5S)-5-Hydroxypiperidine-2-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 63088-78-8
Cat. No. CS-W007250
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(2S,5S)-5-Hydroxypiperidine-2-carboxylic acid|CS-W007250

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General Information

CAS No. 63088-78-8
Cat. No. CS-W007250
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₁NO₃
Molecular Weight 145.16
Synonym(s) cis-5-Hydroxy-L-pipecolic Acid
SMILES O[C@H]1CC[C@@H](C(O)=O)NC1

Description

This chiral piperidine derivative features a hydroxyl group at the 5-position and a carboxylic acid at the 2-position, enabling integration into bioactive scaffolds. The stereochemistry at C2 and C5 imparts defined spatial orientation, enhancing target selectivity in medicinal chemistry applications. Bench-stable and moisture-tolerant, it serves as a key building block for peptide mimetics and CNS-targeted compounds.

Application

(2S,5S)-5-Hydroxypiperidine-2-carboxylic acid serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptidomimetics. Its constrained piperidine core with orthogonal hydroxyl and carboxylic acid functionalities enables selective derivatization in medicinal chemistry workflows. The compound exhibits excellent bench stability and facilitates efficient incorporation into macrocyclic and linear scaffolds via standard coupling and protection strategies.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 69.56
LogP -0.8161
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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(2S,5S)-5-Hydroxypiperidine-2-carboxylic acid

CAS No. 63088-78-8

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