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CS-W001157 4
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2-(2-Chloroethyl)pyridine

  • CAS No. 16927-00-7

  • Cat. No. CS-0096286
  • Purity≥97%
  • MDL No.MFCD06656799

*For research and further manufacturing use only, not for direct human use.

2-(2-Chloroethyl)pyridine|CS-0096286

Structure of 16927-00-7

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General Information

  • CAS No. 16927-00-7
  • Cat. No. CS-0096286
  • Purity ≥97%
  • MDL No. MFCD06656799
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClN
  • Molecular Weight 141.60
  • Synonym(s) 2-(2-BROMOETHYL)PYRIDINE KP-010
  • SMILES ClCCC1=NC=CC=C1

Description

2-(2-Chloroethyl)pyridine features a pyridine ring linked to a chloroethyl side chain, enabling efficient alkylation under mild conditions. This bifunctional scaffold integrates readily into synthetic routes requiring nucleophilic displacement or cyclization. The chlorine atom provides high reactivity for conjugate addition or transition-metal-catalyzed coupling, while the aromatic nitrogen stabilizes adjacent charge development. Ideal for building complex heterocycles and bioactive molecules in medicinal chemistry workflows.

Application

2-(2-Chloroethyl)pyridine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient construction of nitrogen-containing heterocycles. The chloroethyl side chain facilitates nucleophilic substitution reactions with amines, thiols, and other soft nucleophiles, while the pyridine ring provides a stable, electron-deficient scaffold for further functionalization. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for synthesizing targeted bioactive molecules and macrocyclic frameworks.

Synthesis

  • Route1
    • 2-(Pyridin-2-yl)ethan-1-ol Betahistine Impurity|CS-0229488
      103-74-2
    • ~%
    • In-stock
      2-(2-Chloroethyl)pyridine|CS-0096286
      16927-00-7

    References

    • Yakugaku Zasshi, , vol. 72, p. 490 Chem.Abstr., , p. 6418 US2533243 , ;
  • Route2
    • null|null
      109-06-8
    • ~%
    • In-stock
      2-(2-Chloroethyl)pyridine|CS-0096286
      16927-00-7

    References

    • Yakugaku Zasshi, , vol. 72, p. 490 Chem.Abstr., , p. 6418

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.8629
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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