Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Bromo-5-nitro-benzoic acid methyl ester

  • CAS No. 6307-87-5

  • Cat. No. CS-W003593
  • Purity≥98%
  • MDL No.MFCD09258759

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-nitro-benzoic acid methyl ester|CS-W003593

Structure of 6307-87-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 6307-87-5
  • Cat. No. CS-W003593
  • Purity ≥98%
  • MDL No. MFCD09258759
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrNO₄
  • Molecular Weight 260.04
  • Synonym(s) Methyl 3-bromo-5-nitrobenzoate
  • SMILES COC(=O)c1cc(Br)cc(c1)[N+](=O)[O-]

Description

3-Bromo-5-nitro-benzoic acid methyl ester features a bromine atom at the meta position relative to the carboxylate, paired with a strongly electron-withdrawing nitro group para to the ester. This combination enhances electrophilicity for cross-coupling reactions and provides robust stability under standard conditions. The methyl ester serves as a handle for downstream derivatization, enabling efficient access to functionalized aromatic scaffolds in synthetic chemistry workflows.

Application

3-Bromo-5-nitro-benzoic acid methyl ester serves as a versatile building block in synthetic organic chemistry, enabling the construction of substituted heterocycles and pharmaceutical intermediates. Its defined electronic profile—combining an electron-withdrawing nitro group and a bromo handle—facilitates palladium-catalyzed cross-coupling reactions and directed functionalization. The methyl ester provides a stable, bench-ready platform for further derivatization under standard conditions.

Synthesis

  • Route1

    References

    • Khan, Anzar; Hecht, Stefan Chemistry - A European Journal, 2006 , vol. 12, # 18 p. 4764 - 4774
  • Route2
    • null|null
      67-56-1
    • In-stock
      3-Bromo-5-nitrobenzoic acid|CS-W002370
      6307-83-1
    • ~97%
    • In-stock
      3-Bromo-5-nitro-benzoic acid methyl ester|CS-W003593
      6307-87-5

    References

    • Mori, Mattia; Vignaroli, Giulia; Cau, Ylenia; Dinic, Jelena; Hill, Richard; Rossi, Matteo; Colecchia, David; Pesic, Milica; Link, Wolfgang; Chiariello, Mario; Ottmann, Christian; Botta, Maurizio ChemMedChem, 2014 , vol. 9, # 5 p. 973 - 983
  • Route3
    • null|null
      67-56-1
    • In-stock
      Methyl 3-nitrobenzoate|CS-W017167
      618-95-1
    • ~58%
    • In-stock
      3-Bromo-5-nitro-benzoic acid methyl ester|CS-W003593
      6307-87-5

    References

    • Kakuta, Hiroki; Azumaya, Isao; Masu, Hyuma; Matsumura, Mio; Yamaguchi, Kentaro; Kagechika, Hiroyuki; Tanatani, Aya Tetrahedron, 2010 , vol. 66, # 42 p. 8254 - 8260

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   69.44
  • LogP   2.1439
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 6307-87-5 sigma6307-87-5 manufacturer6307-87-5 price6307-87-5 structure6307-87-5 SDSbuy 6307-87-56307-87-5 supplier6307-87-5 uses6307-87-5 molecular weightprice of 6307-87-56307-87-5 chemical name formula of 6307-87-5
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label