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CS-W001157 4
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Methyl 2,6-dichloropyrimidine-4-carboxylate

  • CAS No. 6299-85-0

  • Cat. No. CS-W004814
  • Purity≥96%
  • MDL No.MFCD01941317

*For research and further manufacturing use only, not for direct human use.

Methyl 2,6-dichloropyrimidine-4-carboxylate|CS-W004814

Structure of 6299-85-0

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General Information

  • CAS No. 6299-85-0
  • Cat. No. CS-W004814
  • Purity ≥96%
  • MDL No. MFCD01941317
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂N₂O₂
  • Molecular Weight 207.01
  • Synonym(s) Methyl 2,4-dichloropyrimidine-6-carboxylate
  • SMILES O=C(C1=NC(Cl)=NC(Cl)=C1)OC

Description

Methyl 2,6-dichloropyrimidine-4-carboxylate features a pyrimidine core bearing two chlorine substituents and a methyl ester group, enabling efficient functionalization in heterocyclic synthesis. The electron-deficient ring facilitates nucleophilic substitution reactions, while the ester moiety serves as a handle for further derivatization. This compound demonstrates stability under standard bench conditions and compatibility with diverse reaction media.

Application

Methyl 2,6-dichloropyrimidine-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds prevalent in agrochemicals and pharmaceuticals. The dichloro substitution pattern facilitates selective nucleophilic displacement, while the ester group supports further derivatization via hydrolysis or reduction. Bench-stable and compatible with standard coupling protocols, it functions reliably in multi-step synthetic sequences requiring functional group tolerance and predictable reactivity.

Synthesis

  • Route1

    References

    • Heterocycles, , vol. 67, # 1 p. 135 - 160
  • Route2

    References

    • Heterocycles, , vol. 67, # 1 p. 135 - 160
  • Route3
    • null|null
      3346-64-3
    • ~%
    • In-stock
      Methyl 2,6-dichloropyrimidine-4-carboxylate|CS-W004814
      6299-85-0

    References

    • Heterocycles, , vol. 67, # 1 p. 135 - 160

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.57
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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