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CS-W001157 4
Total: USD 88.00

m-PEG4-Tos

  • CAS No. 62921-76-0

  • Cat. No. CS-0063679
  • Purity≥97%
  • MDL No.MFCD11041134

*For research and further manufacturing use only, not for direct human use.

m-PEG4-Tos|CS-0063679

Structure of 62921-76-0

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General Information

  • CAS No. 62921-76-0
  • Cat. No. CS-0063679
  • Purity ≥97%
  • MDL No. MFCD11041134
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₆O₇S
  • Molecular Weight 362.44
  • Synonym(s) None
  • SMILES CC1=CC=C(C=C1)S(OCCOCCOCCOCCOC)(=O)=O

Description

m-PEG4-Tos features a para-tosylated methoxy-terminated PEG chain, offering enhanced solubility and stability in aqueous and organic media. This derivative enables efficient conjugation workflows, particularly in bioconjugation and surface functionalization applications.

Application

m-PEG4-Tos serves as a versatile bifunctional linker for conjugation and solid-phase synthesis, combining the solubility and stability of a methoxy-terminated PEG4 chain with a tosyl leaving group. It facilitates efficient nucleophilic substitution reactions with amines and thiols, enabling reliable attachment to biomolecules, resins, or functionalized surfaces. The tosyl group provides excellent reactivity under mild conditions, while the PEG spacer enhances solubility and reduces non-specific binding in biological applications.

Synthesis

  • Route1
    • Tetraethylene glycol monomethyl ether HQ|CS-1347367
      23783-42-8
    • null|null
      98-59-9
    • ~99%
    • In-stock
      m-PEG4-Tos|CS-0063679
      62921-76-0

    References

    • Vallee, M. Robert J.; Majkut, Paul; Wilkening, Ina; Weise, Christoph; Mueller, Gregor; Hackenberger, Christian P. R. Organic Letters, 2011 , vol. 13, # 20 p. 5440 - 5443
  • Route2
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • ~%
    • In-stock
      m-PEG4-Tos|CS-0063679
      62921-76-0

    References

    • Mihara, Takashi; Yada, Takahiro; Koide, Naoyuki Molecular Crystals and Liquid Crystals, 2004 , vol. 411, p. 421/[1463]-437/[1479]
  • Route3

    References

    • Selve, Claude; Achilefu, Samuel Journal of the Chemical Society, Chemical Communications, 1990 , # 13 p. 911 - 912

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   80.29
  • LogP   1.39652
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   14

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