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CS-W001157 4
Total: USD 88.00

N-Butyl disulfide

  • CAS No. 629-45-8

  • Cat. No. CS-0204839
  • Purity≥98%
  • MDL No.MFCD00009467

*For research and further manufacturing use only, not for direct human use.

N-Butyl disulfide|CS-0204839

Structure of 629-45-8

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General Information

  • CAS No. 629-45-8
  • Cat. No. CS-0204839
  • Purity ≥98%
  • MDL No. MFCD00009467
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈S₂
  • Molecular Weight 178.36
  • Synonym(s) dibutyl disulphide
  • SMILES S(SCCCC)CCCC

Description

N-Butyl disulfide features a linear alkyl chain flanked by two sulfur atoms, delivering enhanced stability and solubility in nonpolar solvents. This compound serves as a robust sulfur transfer agent in synthetic transformations, enabling efficient incorporation of thiol functionalities under mild conditions.

Application

N-Butyl disulfide serves as a stable, bench-friendly thiol equivalent in synthetic workflows, enabling controlled disulfide formation and reduction. It functions as a versatile building block for sulfur-containing heterocycles and peptide-cysteine analogs, offering excellent functional group tolerance and ease of purification. Its low volatility and thermal stability facilitate reliable use in air-sensitive transformations and scale-up applications.

Synthesis

  • Route1
    • null|null
      542-69-8
    • ~93%
    • In-stock
      N-Butyl disulfide|CS-0204839
      629-45-8

    References

    • Sonavane, Sachin U.; Chidambaram, Mandan; Almog, Joseph; Sasson, Yoel Tetrahedron Letters, 2007 , vol. 48, # 34 p. 6048 - 6050
  • Route2
    • null|null
      71-36-3
    • ~86%
    • In-stock
      N-Butyl disulfide|CS-0204839
      629-45-8

    References

    • Iranpoor, Nasser; Firouzabadi, Habib; Khalili, Dariush Tetrahedron Letters, 2012 , vol. 53, # 51 p. 6913 - 6915
  • Route3
    • null|null
      109-79-5
    • ~99%
    • In-stock
      N-Butyl disulfide|CS-0204839
      629-45-8

    References

    • Kirihara, Masayuki; Okubo, Kumiko; Uchiyama, Tomoyuki; Kato, Yoko; Ochiai, Yuta; Matsushita, Shinya; Hatano, Akihiko; Kanamori, Kan Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 5 p. 625 - 627

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.968
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   7

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