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CS-W001157 4
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Quinolin-4-ylmethanol

  • CAS No. 6281-32-9

  • Cat. No. CS-0019260
  • Purity≥98%
  • MDL No.MFCD01006059

*For research and further manufacturing use only, not for direct human use.

Quinolin-4-ylmethanol|CS-0019260

Structure of 6281-32-9

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General Information

  • CAS No. 6281-32-9
  • Cat. No. CS-0019260
  • Purity ≥98%
  • MDL No. MFCD01006059
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO
  • Molecular Weight 159.18
  • Synonym(s) 4-quinolylmethanol
  • SMILES OCC1=CC=NC2=CC=CC=C12

Description

Quinolin-4-ylmethanol features a quinoline scaffold with a reactive benzylic alcohol, enabling straightforward derivatization. This versatile scaffold integrates readily into bioactive molecules and functional materials, offering enhanced solubility and stability under standard conditions.

Application

Quinolin-4-ylmethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through direct functionalization at the benzylic position. Its bench-stable nature and compatibility with standard coupling reactions facilitate straightforward derivatization for drug discovery applications. The molecule functions as a key scaffold component in kinase inhibitors and other targeted therapeutics, offering predictable reactivity in nucleophilic substitution and oxidation processes.

Synthesis

  • Route1

    References

    • Boutros, Andre; Legros, Jean-Yves; Fiaud, Jean-Claude Tetrahedron, 2000 , vol. 56, # 15 p. 2239 - 2246
  • Route2

    References

    • Bloxham, Jason; Crew, Andrew Phillip; Honda, Ayako; Li, An-Hu; Panicker, Bijoy; Tardibono, Lawrence; Wynne, Graham Michael Patent: US2005/154014 A1, 2005 ;
  • Route3

    References

    • Zymalkowski Archiv der Pharmazie (Weinheim, Germany), 1959 , vol. 292, p. 682,690

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.7271
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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