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CS-W001157 4
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2-(3-(Difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 627525-89-7

  • Cat. No. CS-0135495
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(3-(Difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0135495

Structure of 627525-89-7

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General Information

  • CAS No. 627525-89-7
  • Cat. No. CS-0135495
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇BF₂O₂
  • Molecular Weight 254.08
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=CC=CC(C(F)F)=C2)O1

Description

This boronate ester features a difluoromethyl-substituted phenyl group coupled to a stable tetramethyl-1,3,2-dioxaborolane ring. It enables efficient Suzuki-Miyaura cross-coupling under standard conditions, delivering arylated products with high functional group tolerance and minimal decomposition.

Application

2-(3-(Difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boron reagent for Suzuki-Miyaura cross-coupling reactions. Its difluoromethyl-substituted aryl group enables efficient incorporation of fluorinated aromatic motifs into complex molecular architectures. The tetramethyl-substituted dioxaborolane framework ensures high chemical stability, minimal protodeboronation, and compatibility with diverse reaction conditions, facilitating reliable C–C bond formation in medicinal chemistry and materials synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.9234
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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