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CS-W001157 4
Total: USD 88.00

Ipidacrine

  • CAS No. 62732-44-9

  • Cat. No. CS-0071577
  • Purity≥97%
  • MDL No.MFCD00618424

*For research and further manufacturing use only, not for direct human use.

Ipidacrine|CS-0071577

Structure of 62732-44-9

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General Information

  • CAS No. 62732-44-9
  • Cat. No. CS-0071577
  • Purity ≥97%
  • MDL No. MFCD00618424
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆N₂
  • Molecular Weight 188.27
  • Synonym(s) NIK-247 (free base); Amiridine (free base)
  • SMILES NC1=C2CCCC2=NC3=C1CCCC3

Description

Ipidacrine is a potent, bench-stable acridine derivative engineered for efficient DNA intercalation. This electron-rich heterocycle integrates seamlessly into nucleic acid duplexes, offering enhanced binding affinity and sequence-selective recognition. Its robust stability under standard conditions enables reliable use in biochemical assays and cellular studies.

Application

Ipidacrine serves as a versatile building block for heterocyclic synthesis, particularly in the construction of quinoline and acridine scaffolds relevant to medicinal chemistry. Its planar, polycyclic structure exhibits robust bench stability and facilitates electrophilic substitution reactions under mild conditions. The molecule functions effectively in coupling protocols requiring aromatic nitrogen incorporation, enabling efficient access to bioactive analogs with predictable reactivity profiles.

Synthesis

  • Route1
    • 1',5',6',7'-Tetrahydrospiro[cyclohexane-1,2'-cyclopenta[d]pyrimidin]-4'(3'H)-one|CS-0071742
      58996-10-4
    • ~76%
    • In-stock
      Ipidacrine|CS-0071577
      62732-44-9

    References

    • Upadysheva, A. V.; Grigor'eva, N. D.; Ryabokobylko, Yu. S.; Znamenskaya, A. P. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 95 - 99 Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 1 p. 107 - 111
  • Route2
    • null|null
      108-94-1
    • In-stock
      2-Amino-1-cyclopentene-1-carbonitrile|CS-W002642
      2941-23-3
    • ~%
    • In-stock
      Ipidacrine|CS-0071577
      62732-44-9

    References

    • Pharmaceutical Chemistry Journal, , vol. 26, # 9-10 p. 769 - 772 Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 9-10 p. 83 - 85

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.0313
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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