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3-Amino-N,N-dimethylbenzenesulfonamide

  • CAS No. 6274-18-6

  • Cat. No. CS-0151272
  • Purity≥98%
  • MDL No.MFCD00602451

*For research and further manufacturing use only, not for direct human use.

3-Amino-N,N-dimethylbenzenesulfonamide|CS-0151272

Structure of 6274-18-6

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General Information

  • CAS No. 6274-18-6
  • Cat. No. CS-0151272
  • Purity ≥98%
  • MDL No. MFCD00602451
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₂O₂S
  • Molecular Weight 200.26
  • Synonym(s) 3-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE
  • SMILES CN(C)S(=O)(=O)C1=CC=CC(=C1)N

Description

3-Amino-N,N-dimethylbenzenesulfonamide features a sulfonamide group flanked by an electron-rich amine and sterically shielded dimethyl substituent, enabling robust conjugation in medicinal chemistry. This bench-stable scaffold integrates readily into bioactive molecules, offering enhanced solubility and metabolic resilience in drug discovery applications.

Application

3-Amino-N,N-dimethylbenzenesulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of sulfonamide-containing scaffolds through straightforward amide coupling and electrophilic substitution reactions. The dimethylamino group enhances solubility and modulates electronic properties, while the primary amine facilitates conjugation and derivatization. Its bench-stable nature and compatibility with standard purification protocols make it well-suited for high-throughput synthesis and process-scale applications.

Synthesis

  • Route1
    • N,N-Dimethyl-3-nitrobenzenesulfonamide|CS-0661149
      26199-83-7
    • ~%
    • In-stock
      3-Amino-N,N-dimethylbenzenesulfonamide|CS-0151272
      6274-18-6

    References

    • US6503949 B1, ; US 6503949 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.4
  • LogP   0.5191
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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