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CS-W001157 4
Total: USD 88.00

Tacrine

  • CAS No. 321-64-2

  • Cat. No. CS-0035017
  • Purity≥98%
  • MDL No.MFCD00046923

*For research and further manufacturing use only, not for direct human use.

Tacrine|CS-0035017

Structure of 321-64-2

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General Information

  • CAS No. 321-64-2
  • Cat. No. CS-0035017
  • Purity ≥98%
  • MDL No. MFCD00046923
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₄N₂
  • Molecular Weight 198.26
  • Synonym(s) None
  • SMILES NC1=C2CCCCC2=NC3=CC=CC=C31

Description

Tacrine serves as a potent acetylcholinesterase inhibitor, featuring a heterocyclic core that enables effective interaction with the enzyme's active site. This compound demonstrates robust activity in cholinergic pathways, supporting its use in neurochemical research and the study of cognitive function.

Application

Tacrine serves as a well-established acetylcholinesterase inhibitor, historically utilized in the study of cholinergic pathways and Alzheimer’s disease therapeutics. Its tricyclic structure provides a robust scaffold for medicinal chemistry exploration, demonstrating consistent reactivity in functional group modifications and serving as a benchmark for central nervous system-targeted compound design.

Synthesis

  • Route1
    • null|null
      108-94-1
    • In-stock
      2-Aminobenzonitrile|CS-W013598
      1885-29-6
    • ~92%
    • In-stock
      Tacrine|CS-0035017
      321-64-2

    References

    • Khalilzadeh, Mohammad A.; Hosseini, Abolfazl; Tajbakhsh', Mahmoud Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 3 p. 535 - 538
  • Route2
    • null|null
      110166-26-2
    • ~61%
    • In-stock
      Tacrine|CS-0035017
      321-64-2
    • null|null
      127842-41-5
    • 9,10-Dihydroacridin-9-amine|CS-1157384
      114990-34-0
    • Octahydroaminoacridine|CS-0863812
      13415-07-1

    References

    • Chemistry Letters, , # 2 p. 319 - 322
  • Route3
    • null|null
      110166-26-2
    • ~59%
    • In-stock
      Tacrine|CS-0035017
      321-64-2
    • null|null
      127842-43-7
    • 9,10-Dihydroacridin-9-amine|CS-1157384
      114990-34-0
    • Octahydroaminoacridine|CS-0863812
      13415-07-1

    References

    • Chemistry Letters, , # 2 p. 319 - 322

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H315-H319-H331-H335-H351
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.6958
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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