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CS-W001157 4
Total: USD 88.00

6-Chlorothieno[2,3-b]pyridine

  • CAS No. 62226-18-0

  • Cat. No. CS-0084705
  • Purity≥98%
  • MDL No.MFCD18253768

*For research and further manufacturing use only, not for direct human use.

6-Chlorothieno[2,3-b]pyridine|CS-0084705

Structure of 62226-18-0

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General Information

  • CAS No. 62226-18-0
  • Cat. No. CS-0084705
  • Purity ≥98%
  • MDL No. MFCD18253768
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClNS
  • Molecular Weight 169.63
  • Synonym(s) None
  • SMILES ClC1=CC=C(C=CS2)C2=N1

Description

6-Chlorothieno[2,3-b]pyridine is a heterocyclic scaffold featuring a chlorinated thienopyridine core, offering enhanced electron-withdrawing character and structural rigidity. This motif integrates readily into pharmaceutical intermediates and advanced materials, where its halogenated site enables efficient cross-coupling transformations under standard conditions.

Application

6-Chlorothieno[2,3-b]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and materials science. The chlorine substituent enables palladium-catalyzed cross-coupling reactions, facilitating the construction of biaryl architectures. Its fused tricyclic structure exhibits good bench stability and functional group tolerance, making it suitable for modular synthesis of advanced API candidates and functional organic semiconductors.

Synthesis

  • Route1
    • 2-Bromo-6-chlorothieno[2,3-b]pyridine|CS-0084888
      68236-35-1
    • ~85%
    • In-stock
      6-Chlorothieno[2,3-b]pyridine|CS-0084705
      62226-18-0

    References

    • Nurkkala, Lasse J.; Steen, Robert O.; Dunne, Simon J. Synthesis, 2006 , # 8 p. 1295 - 1300
  • Route2

    References

    • Nurkkala, Lasse J.; Steen, Robert O.; Dunne, Simon J. Synthesis, 2006 , # 8 p. 1295 - 1300
  • Route3

    References

    • Barker, John M.; Huddleston, Patrick R.; Holmes, David Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.9497
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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