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CS-W001157 4
Total: USD 88.00

4-Chlorothieno[2,3-b]pyridine

  • CAS No. 62226-17-9

  • Cat. No. CS-0084899
  • Purity≥98%
  • MDL No.MFCD11858513

*For research and further manufacturing use only, not for direct human use.

4-Chlorothieno[2,3-b]pyridine|CS-0084899

Structure of 62226-17-9

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General Information

  • CAS No. 62226-17-9
  • Cat. No. CS-0084899
  • Purity ≥98%
  • MDL No. MFCD11858513
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClNS
  • Molecular Weight 169.63
  • Synonym(s) 6-methylthieno[2,3-b]pyridin-3-amine
  • SMILES ClC1=C2C(SC=C2)=NC=C1

Description

4-Chlorothieno[2,3-b]pyridine features a fused thienopyridine core with a chlorine substituent at the 4-position, delivering enhanced electron-deficiency and improved stability for use in cross-coupling reactions. This heterocyclic scaffold integrates readily into bioactive molecules and functional materials, offering predictable reactivity under standard conditions.

Application

4-Chlorothieno[2,3-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of fused thienopyridine scaffolds. Its chlorine substituent facilitates palladium-catalyzed cross-coupling reactions, while the electron-deficient core exhibits favorable reactivity in nucleophilic substitution and C–H functionalization processes. The compound demonstrates excellent bench stability and compatibility with standard purification techniques, making it well-suited for scalable synthesis and structure-activity studies.

Synthesis

  • Route1
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    • In-stock
      4-Chlorothieno[2,3-b]pyridine|CS-0084899
      62226-17-9

    References

    • Khan,M.A.; Guarconi,A.E. Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
  • Route2

    References

    • Khan,M.A.; Guarconi,A.E. Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
  • Route3
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      110651-85-9
    • ~%
    • In-stock
      4-Chlorothieno[2,3-b]pyridine|CS-0084899
      62226-17-9

    References

    • Klemm,L.H.; Hartling,R. Journal of Heterocyclic Chemistry, 1976 , vol. 13, p. 1197 - 1200

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.9497
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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