Ethyl 2,4-dichloronicotinate

Name: Ethyl 2,4-dichloronicotinate
Brand: ChemScene
Availability: InStock
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CAS No. 62022-04-2
Cat. No. CS-W006017
Purity≥98%
MDL No.MFCD12407388

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Structure of 62022-04-2

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General Information

CAS No. 62022-04-2
Cat. No. CS-W006017
Purity ≥98%
MDL No. MFCD12407388
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇Cl₂NO₂
Molecular Weight 220.05
Synonym(s) ethyldichloronicotinate
SMILES O=C(OCC)C1=C(Cl)N=CC=C1Cl

Description

Ethyl 2,4-dichloronicotinate serves as a key synthetic intermediate in the construction of bioactive heterocycles. The electron-deficient pyridine core, flanked by chloro substituents at the 2- and 4-positions, enhances reactivity in nucleophilic substitution and cross-coupling processes. This ester functionality enables straightforward derivatization under standard conditions, supporting efficient access to pharmaceutical and agrochemical scaffolds.

Application

Ethyl 2,4-dichloronicotinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted nicotinates and heterocyclic scaffolds. Its dual chloro substituents at C-2 and C-4 position facilitate selective nucleophilic substitution, while the ester group supports further functionalization. The compound exhibits excellent bench stability and ease of purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

Route1
- In-stock
  
  26452-80-2
- ~41%
- In-stock
  
  62022-04-2
References
- GENENTECH, INC. Patent: WO2008/24725 A1, 2008 ; Location in patent: Page/Page column 106-107 ; WO 2008/024725 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 39.19
LogP 2.5651
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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Ethyl 2,4-dichloronicotinate

CAS No. 62022-04-2

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