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CS-W001157 4
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Pyrimidine-2-carbaldehyde

  • CAS No. 27427-92-5

  • Cat. No. CS-0048725
  • Purity≥97%
  • MDL No.MFCD07778416

*For research and further manufacturing use only, not for direct human use.

Pyrimidine-2-carbaldehyde|CS-0048725

Structure of 27427-92-5

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General Information

  • CAS No. 27427-92-5
  • Cat. No. CS-0048725
  • Purity ≥97%
  • MDL No. MFCD07778416
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂O
  • Molecular Weight 108.10
  • Synonym(s) Pyrimidine-2-carboxaldehyde
  • SMILES O=CC1=NC=CC=N1

Description

Pyrimidine-2-carbaldehyde features a reactive aldehyde group at the 2-position of a pyrimidine ring, enabling direct incorporation into heterocyclic architectures. This electron-deficient scaffold serves as a key building block for medicinal chemistry and materials science applications.

Application

Pyrimidine-2-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds. Its aldehyde functionality facilitates nucleophilic additions, reductive aminations, and condensation reactions under standard conditions. The molecule exhibits good bench stability and compatibility with diverse functional groups, supporting straightforward purification and integration into multi-step syntheses.

Synthesis

  • Route1

    References

    • Bridger, Gary; Skerlj, Renato; Kaller, Ai; Harwig, Curtis; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher Dennis; Di Fluri, Maria Rosaria Patent: US2003/220341 A1, 2003 ; Location in patent: Page/Page column 29; 62 ; US 20030220341 A1
  • Route2

    References

    • Lewandowska, Elzbieta; Chatfield, David C. European Journal of Organic Chemistry, 2005 , # 15 p. 3297 - 3303

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   42.85
  • LogP   0.2891
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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