Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-(Pyrimidin-2-yl)ethan-1-one

  • CAS No. 53342-27-1

  • Cat. No. CS-W003508
  • Purity≥98%
  • MDL No.MFCD08361636

*For research and further manufacturing use only, not for direct human use.

1-(Pyrimidin-2-yl)ethan-1-one|CS-W003508

Structure of 53342-27-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 53342-27-1
  • Cat. No. CS-W003508
  • Purity ≥98%
  • MDL No. MFCD08361636
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O
  • Molecular Weight 122.12
  • Synonym(s) Ethanone, 1-(2-pyrimidinyl)-
  • SMILES CC(C1=NC=CC=N1)=O

Description

1-(Pyrimidin-2-yl)ethan-1-one features a pyrimidine ring directly fused to an acetyl group, delivering a potent electron-deficient heterocyclic scaffold. This configuration enables direct incorporation into conjugated systems and facilitates transition-metal-catalyzed cross-coupling reactions. The compound exhibits enhanced stability under standard conditions and demonstrates favorable solubility in common organic solvents, supporting its use in synthetic methodology development and pharmaceutical intermediate synthesis.

Application

1-(Pyrimidin-2-yl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-containing scaffolds via nucleophilic addition and condensation reactions. Its ketone functionality exhibits good bench stability and facilitates straightforward functionalization, including enolization and conjugate addition. The molecule functions effectively in coupling protocols and heterocycle synthesis, offering predictable reactivity and clean purification profiles, making it well-suited for high-throughput screening and process-scale applications.

Synthesis

  • Route1
    • In-stock
      2-Cyanopyrimidine|CS-D1157
      14080-23-0
    • null|null
      75-16-1
    • ~72%
    • In-stock
      1-(Pyrimidin-2-yl)ethan-1-one|CS-W003508
      53342-27-1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2008/117051 A1, 2008 ; Location in patent: Page/Page column 37 ; WO 2008/117051 A1
  • Route2
    • In-stock
      2-Cyanopyrimidine|CS-D1157
      14080-23-0
    • null|null
      917-64-6
    • ~29%
    • In-stock
      1-(Pyrimidin-2-yl)ethan-1-one|CS-W003508
      53342-27-1

    References

    • Cibulka, Radek; Hampl, Frantisek; Martinu, Tomas; Mazac, Jiri; Totevova, Sonja; Liska, Frantisek Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 7 p. 1159 - 1179

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   42.85
  • LogP   0.6792
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1-(Pyrimidin-2-yl)ethan-1-one sigma1-(Pyrimidin-2-yl)ethan-1-one manufacturer1-(Pyrimidin-2-yl)ethan-1-one price1-(Pyrimidin-2-yl)ethan-1-one structure1-(Pyrimidin-2-yl)ethan-1-one SDSbuy 1-(Pyrimidin-2-yl)ethan-1-one1-(Pyrimidin-2-yl)ethan-1-one supplier1-(Pyrimidin-2-yl)ethan-1-one uses1-(Pyrimidin-2-yl)ethan-1-one molecular weightprice of 1-(Pyrimidin-2-yl)ethan-1-one1-(Pyrimidin-2-yl)ethan-1-one chemical name formula of 1-(Pyrimidin-2-yl)ethan-1-one
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label