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CS-W001157 4
Total: USD 88.00

Methyl 3-hydroxypropanoate

  • CAS No. 6149-41-3

  • Cat. No. CS-0022864
  • Purity≥96%
  • MDL No.MFCD00272293

*For research and further manufacturing use only, not for direct human use.

Methyl 3-hydroxypropanoate|CS-0022864

Structure of 6149-41-3

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General Information

  • CAS No. 6149-41-3
  • Cat. No. CS-0022864
  • Purity ≥96%
  • MDL No. MFCD00272293
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O₃
  • Molecular Weight 104.10
  • Synonym(s) None
  • SMILES O=C(OC)CCO

Description

Methyl 3-hydroxypropanoate is a versatile β-hydroxy ester featuring a pendant hydroxyl group and a methyl ester functionality. This bifunctional molecule enables direct incorporation into synthetic sequences, serving as a key building block for polyesters, pharmaceutical intermediates, and chiral auxiliaries. The hydroxyl moiety enhances solubility in polar solvents and supports downstream derivatization through selective protection or coupling reactions.

Application

Methyl 3-hydroxypropanoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to γ-hydroxy esters and related heterocycles. Its hydroxyl and ester functionalities exhibit good bench stability and compatibility with common protecting group strategies. The compound participates reliably in esterification, etherification, and cyclization reactions, facilitating the construction of oxygen-containing scaffolds relevant to medicinal chemistry and natural product synthesis.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      Propiolactone|CS-0030919
      57-57-8
    • ~97%
    • In-stock
      Methyl 3-hydroxypropanoate|CS-0022864
      6149-41-3

    References

    • Hollowood, Christopher J.; Yamanoi, Shigeo; Ley, Steven V. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 10 p. 1664 - 1675
  • Route2
    • null|null
      75-21-8
    • null|null
      67-56-1
    • In-stock
      Me-PEG4-Me|CS-W014238
      143-24-8
    • null|null
      201230-82-2
    • ~81%
    • In-stock
      Methyl 3-hydroxypropanoate|CS-0022864
      6149-41-3

    References

    • Samsung Electronics Co. Ltd. Patent: US6348632 B1, 2002 ; Location in patent: Page column 7-8 ;
  • Route3
    • null|null
      75-21-8
    • In-stock
      Me-PEG4-Me|CS-W014238
      143-24-8
    • null|null
      201230-82-2
    • ~83%
    • null|null
      109-86-4
    • In-stock
      Methyl 3-hydroxypropanoate|CS-0022864
      6149-41-3
    • null|null
      27313-49-1
    • null|null
      75-07-0

    References

    • Samsung Electronics Co. Ltd. Patent: US6348632 B1, 2002 ; Location in patent: Page column 8-10 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.4582
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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