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CS-W001157 4
Total: USD 88.00

trans-4-Methoxycyclohexanamine hydrochloride

  • CAS No. 61367-41-7

  • Cat. No. CS-0094718
  • Purity≥97%
  • MDL No.MFCD18207785

*For research and further manufacturing use only, not for direct human use.

trans-4-Methoxycyclohexanamine hydrochloride|CS-0094718

Structure of 61367-41-7

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General Information

  • CAS No. 61367-41-7
  • Cat. No. CS-0094718
  • Purity ≥97%
  • MDL No. MFCD18207785
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆ClNO
  • Molecular Weight 165.66
  • Synonym(s) trans-4-Methoxycyclohexanamine HCl
  • SMILES N[C@H]1CC[C@H](OC)CC1.Cl

Description

trans-4-Methoxycyclohexanamine hydrochloride features a stable, bench-stable cyclohexane scaffold with a methoxy group at the equatorial position, enhancing solubility and metabolic stability. This configuration enables efficient incorporation into bioactive scaffolds, particularly in medicinal chemistry applications requiring precise stereochemical control and improved pharmacokinetic profiles.

Application

trans-4-Methoxycyclohexanamine hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmacologically relevant scaffolds. Its stable trans configuration and bench-ready hydrochloride salt form facilitate handling, purification, and incorporation into diverse coupling and functionalization reactions, offering predictable stereochemical control and broad compatibility with standard synthetic protocols.

Synthesis

  • Route1
    • Tert-butyl (4-methoxycyclohexyl)carbamate|CS-0540961
      760958-17-6
    • ~88%
    • In-stock
      trans-4-Methoxycyclohexanamine hydrochloride|CS-0094718
      61367-41-7

    References

    • Kawanishi, Eiji; Matsumura, Takehiko Patent: US2011/160206 A1, 2011 ; Location in patent: Page/Page column 28 ;
  • Route2

    References

    • Kawanishi, Eiji; Matsumura, Takehiko Patent: US2011/160206 A1, 2011 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.9606
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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