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CS-W001157 4
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trans-4-Methoxycyclohexan-1-amine

  • CAS No. 121588-79-2

  • Cat. No. CS-0047753
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

trans-4-Methoxycyclohexan-1-amine|CS-0047753

Structure of 121588-79-2

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General Information

  • CAS No. 121588-79-2
  • Cat. No. CS-0047753
  • Purity ≥95%
  • MDL No. None
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO
  • Molecular Weight 129.20
  • Synonym(s) trans-4-Methoxycyclohexanamine
  • SMILES N[C@H]1CC[C@H](OC)CC1

Description

trans-4-Methoxycyclohexan-1-amine features a stable trans-diaxial arrangement that imparts conformational rigidity, enhancing its utility in stereocontrolled synthesis. The methoxy group provides polar solubility and modulates electronic effects, while the primary amine serves as a robust coupling handle for diversification. This scaffold enables efficient access to bioactive heterocycles and functional materials under standard conditions.

Application

trans-4-Methoxycyclohexan-1-amine serves as a versatile chiral building block in medicinal chemistry, offering a rigid, conformationally defined scaffold with orthogonal functional handles. The amine group enables facile derivatization via acylation, alkylation, or reductive amination, while the methoxy substituent provides steric and electronic modulation. Its bench-stable nature and compatibility with standard purification protocols make it well-suited for iterative synthesis workflows and target-oriented library development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.9027
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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