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CS-W001157 4
Total: USD 88.00

1-Fluoro-4-methoxy-2-nitrobenzene

  • CAS No. 61324-93-4

  • Cat. No. CS-W007748
  • Purity≥97%
  • MDL No.MFCD11848442

*For research and further manufacturing use only, not for direct human use.

1-Fluoro-4-methoxy-2-nitrobenzene|CS-W007748

Structure of 61324-93-4

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General Information

  • CAS No. 61324-93-4
  • Cat. No. CS-W007748
  • Purity ≥97%
  • MDL No. MFCD11848442
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₃
  • Molecular Weight 171.13
  • Synonym(s) benzene, 1-fluoro-4-methoxy-2-nitro-
  • SMILES O=[N+](C1=CC(OC)=CC=C1F)[O-]

Description

1-Fluoro-4-methoxy-2-nitrobenzene features a strategically positioned fluorine atom and electron-withdrawing nitro group that enhance reactivity in nucleophilic aromatic substitution, while the methoxy substituent improves solubility and stability under standard conditions.

Application

1-Fluoro-4-methoxy-2-nitrobenzene serves as a versatile aryl building block in nucleophilic aromatic substitution reactions, enabling efficient access to functionalized anilines and heterocycles. The ortho-nitro group enhances electrophilicity at the fluorine-bearing position, facilitating reaction with amines, thiols, and other nucleophiles under mild conditions. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for iterative synthesis in medicinal chemistry and agrochemical development.

Synthesis

  • Route1
    • In-stock
      4-Fluoro-3-nitrophenol|CS-W004934
      2105-96-6
    • null|null
      74-88-4
    • ~80%
    • In-stock
      1-Fluoro-4-methoxy-2-nitrobenzene|CS-W007748
      61324-93-4

    References

    • Widdowson, David A.; Wilhelm, Rene Chemical Communications, 2003 , # 5 p. 578 - 579

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.37
  • LogP   1.7425
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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