2-Chloro-4-fluorobenzonitrile

Name: 2-Chloro-4-fluorobenzonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 60702-69-4
Cat. No. CS-W018016
Purity≥98%
MDL No.MFCD00042523

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-fluorobenzonitrile|CS-W018016

Structure of 60702-69-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 60702-69-4
Cat. No. CS-W018016
Purity ≥98%
MDL No. MFCD00042523
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClFN
Molecular Weight 155.56
Synonym(s) 2-chloro-4-fluorobenzenecarbonitrile
SMILES C1=C(C(=CC=C1F)C#N)Cl

Description

2-Chloro-4-fluorobenzonitrile features a dual halogenated aromatic core with orthogonal electron-withdrawing substituents, enabling selective coupling in cross-coupling reactions. The nitrile group provides a robust handle for downstream functionalization, while the fluorine and chlorine atoms offer enhanced metabolic stability and favorable electronic tuning for medicinal chemistry applications.

Application

2-Chloro-4-fluorobenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed coupling reactions. Its ortho-chloro and meta-fluoro substituents provide orthogonal reactivity for sequential functionalization, while the nitrile group supports diverse transformations including hydrolysis to carboxylic acids or reduction to aldehydes. The compound exhibits excellent bench stability and compatibility with standard purification methods, facilitating integration into multi-step synthetic sequences.

Synthesis

Route1
- In-stock
  
  28163-00-0
- ~93%
- In-stock
  
  60702-69-4
References
- LaBeaume, Paul; Placzek, Michael; Daniels, Mathew; Kendrick, Ian; Ng, Patrick; McNeel, Melissa; Afroze, Roushan; Alexander, Abigail; Thomas, Rhiannon; Kallmerten, Amy E.; Jones, Graham B. Tetrahedron Letters, 2010 , vol. 51, # 14 p. 1906 - 1909
Route2
- In-stock
  
  28163-00-0
- ~92%
- In-stock
  
  3939-09-1
- In-stock
  
  60702-69-4
References
- Journal of Fluorine Chemistry, , vol. 63, # 1-2 p. 25 - 30

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 23.79
LogP 2.35078
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

2-Chloro-4-fluorobenzonitrile sigma2-Chloro-4-fluorobenzonitrile manufacturer2-Chloro-4-fluorobenzonitrile price2-Chloro-4-fluorobenzonitrile structure2-Chloro-4-fluorobenzonitrile SDSbuy 2-Chloro-4-fluorobenzonitrile2-Chloro-4-fluorobenzonitrile supplier2-Chloro-4-fluorobenzonitrile uses2-Chloro-4-fluorobenzonitrile molecular weightprice of 2-Chloro-4-fluorobenzonitrile2-Chloro-4-fluorobenzonitrile chemical name formula of 2-Chloro-4-fluorobenzonitrile

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2-Chloro-4-fluorobenzonitrile

CAS No. 60702-69-4

Recommended Products