2-Chloro-6-(trifluoromethyl)benzaldehyde

Name: 2-Chloro-6-(trifluoromethyl)benzaldehyde
Brand: ChemScene
Availability: InStock
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CAS No. 60611-22-5
Cat. No. CS-0042714
Purity≥95%
MDL No.MFCD06660231

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-6-(trifluoromethyl)benzaldehyde|CS-0042714

Structure of 60611-22-5

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General Information

CAS No. 60611-22-5
Cat. No. CS-0042714
Purity ≥95%
MDL No. MFCD06660231
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄ClF₃O
Molecular Weight None
Synonym(s) Benzaldehyde,2-chloro-6-(trifluoromethyl)
SMILES FC(F)(F)C1=CC=CC(Cl)=C1C=O

Description

2-Chloro-6-(trifluoromethyl)benzaldehyde features a trifluoromethyl group that imparts strong electron-withdrawing character, enhancing reactivity in nucleophilic additions. The ortho-chloro substituent provides steric and electronic modulation, while the aldehyde functionality enables direct coupling in synthesis. This compound serves as a key building block for pharmaceutical intermediates and functional materials.

Application

2-Chloro-6-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of biologically relevant heterocycles. Its orthogonal reactivity profile—combining a stable aldehyde functionality with electron-withdrawing chlorine and trifluoromethyl groups—facilitates diverse transformations including nucleophilic additions, Suzuki couplings, and condensation reactions. The compound exhibits excellent bench stability and is readily purified by distillation or recrystallization, supporting scalable synthesis workflows.

Synthesis

Route1
- 98-15-7
- 68-12-2
- ~%
- In-stock
  
  60611-22-5
References
- Wang, Le; Wang, Yan; Guo, Fangxu; Zheng, Yue; Bhadury, Pinaki S.; Sun, Zhihua Tetrahedron Letters, 2013 , vol. 54, # 45 p. 6053 - 6056
Route2
- In-stock
  
  2376-00-3
- ~%
- In-stock
  
  60611-22-5
References
- MERCK SHARP and DOHME CORP.; BARR, Kenneth Jay; BEINSTOCK, Corey; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas Patent: WO2014/26329 A1, 2014 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 17.07
LogP 3.1713
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-6-(trifluoromethyl)benzaldehyde

CAS No. 60611-22-5

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