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CS-W001157 4
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4-Chloro-2-fluoronicotinaldehyde

  • CAS No. 1232432-20-0

  • Cat. No. CS-0043903
  • Purity≥95%
  • MDL No.MFCD15143389

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-fluoronicotinaldehyde|CS-0043903

Structure of 1232432-20-0

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General Information

  • CAS No. 1232432-20-0
  • Cat. No. CS-0043903
  • Purity ≥95%
  • MDL No. MFCD15143389
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO
  • Molecular Weight 159.55
  • Synonym(s) 4-chloro-2-fluoropyridine-3-carbaldehyde
  • SMILES O=CC1=C(F)N=CC=C1Cl

Description

4-Chloro-2-fluoronicotinaldehyde features a highly reactive aldehyde group flanked by electron-withdrawing chlorine and fluorine substituents, enhancing its utility in nucleophilic addition reactions. This bench-stable compound integrates readily into complex heterocyclic scaffolds and serves as a key building block for pharmaceutical intermediates and functional materials.

Application

4-Chloro-2-fluoronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocycles and bioactive scaffolds. Its ortho-fluoro and para-chloro substituents enhance electrophilicity at the aldehyde carbon, facilitating nucleophilic addition and condensation reactions. The compound exhibits good bench stability and compatibility with common reaction conditions, supporting straightforward purification and integration into multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.6866
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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