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CS-W001157 4
Total: USD 88.00

9,9-Dimethyl-2-nitro-9H-fluorene

  • CAS No. 605644-46-0

  • Cat. No. CS-0041635
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

9,9-Dimethyl-2-nitro-9H-fluorene|CS-0041635

Structure of 605644-46-0

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General Information

  • CAS No. 605644-46-0
  • Cat. No. CS-0041635
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₃NO₂
  • Molecular Weight 239.27
  • Synonym(s) 9,9-Dimethyl-2-nitrofluorene; 9,9-Dimethyl-2-nitro-9H-fluorene
  • SMILES O=[N+](C1=CC(C(C)(C)C2=C3C=CC=C2)=C3C=C1)[O-]

Description

9,9-Dimethyl-2-nitro-9H-fluorene features a rigid, polycyclic fluorene core with a sterically shielded dimethyl substitution at the 9-position, enhancing stability. The para-nitro group imparts strong electron-withdrawing character, enabling participation in cross-coupling reactions and serving as a handle for further functionalization. This compound exhibits excellent bench stability and solubility in common organic solvents, facilitating use in synthetic workflows.

Application

9,9-Dimethyl-2-nitro-9H-fluorene serves as a stable, bench-accessible building block for the synthesis of fluorene-based heterocycles and functionalized aromatic scaffolds. Its nitro group enables selective reduction to an amine, while the sterically protected fluorene core supports diverse coupling reactions and electrophilic transformations. The dimethyl substitution enhances solubility and thermal stability, facilitating purification and scale-up in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.14
  • LogP   3.9011
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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