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Structure of 60395-90-6
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4-Chloro-6-methoxy-2-methylquinazoline is a bench-stable, electron-deficient quinazoline scaffold featuring a chlorine at C4 and a methoxy group at C6. This substitution pattern enhances its utility in medicinal chemistry for targeted kinase inhibition and as a building block in pharmaceutical discovery workflows.
4-Chloro-6-methoxy-2-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted quinazoline scaffolds via palladium-catalyzed cross-coupling reactions. The chloro group at the 4-position provides high reactivity for Suzuki, Stille, and Buchwald–Hartwig transformations, while the methoxy and methyl substituents offer favorable electronic and steric profiles. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for parallel synthesis campaigns and API intermediate development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: