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CS-W001157 4
Total: USD 88.00

4-Methyl-1,2,3-thiadiazole-5-carboxylic acid

  • CAS No. 18212-21-0

  • Cat. No. CS-B1141
  • Purity≥97%
  • MDL No.MFCD00173830
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Methyl-1,2,3-thiadiazole-5-carboxylic acid|CS-B1141

Structure of 18212-21-0

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Description

4-Methyl-1,2,3-thiadiazole-5-carboxylic acid features a fused heterocyclic core with dual electron-deficient sites, enabling robust coupling reactions. The methyl group enhances solubility and steric resilience, while the carboxylic acid moiety offers direct functionalization potential. This scaffold delivers stability under standard conditions and integrates readily into bioactive molecule design.

Application

4-Methyl-1,2,3-thiadiazole-5-carboxylic acid serves as a versatile heterocyclic building block in medicinal and process chemistry, enabling efficient access to bioactive scaffolds. Its carboxylic acid functionality facilitates direct coupling reactions, while the 1,2,3-thiadiazole ring provides metabolic stability and favorable electronic properties. The methyl substituent enhances solubility and modulates reactivity, supporting broad functional group tolerance. This compound functions reliably in standard amide formation, esterification, and transition metal-catalyzed transformations, making it well-suited for high-throughput synthesis and scale-up applications.

General Information

  • CAS No. 18212-21-0
  • Cat. No. CS-B1141
  • Purity ≥97%
  • MDL No. MFCD00173830
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄N₂O₂S
  • Molecular Weight 144.15
  • Synonym(s) 4-methyl-1,2,3-thiadiazole-5-carboxylate
  • SMILES O=C(C1=C(C)N=NS1)O

Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.54472
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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