Boc-Met(O2)-OH

Name: Boc-Met(O2)-OH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 60280-45-7
Cat. No. CS-0187742
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 60280-45-7

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General Information

CAS No. 60280-45-7
Cat. No. CS-0187742
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉NO₆S
Molecular Weight 281.33
Synonym(s) Boc-L-methionine sulfone
SMILES CC(C)(OC(N[C@H](C(O)=O)CCS(=O)(C)=O)=O)C

Description

Boc-Met(O2)-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a protected methionine side chain with a labile O₂-protected sulfide. This orthogonal protection scheme enables selective deprotection during peptide synthesis workflows. The Boc group facilitates efficient coupling under standard conditions, while the O₂-protected moiety resists premature oxidation. Ideal for incorporating oxidatively sensitive methionine residues into complex sequences.

Application

Boc-Met(O2)-OH serves as a protected methionine building block for peptide synthesis, offering stable incorporation of the methionine side chain with orthogonal protection. The Boc group enables mild deprotection under acidic conditions, while the O₂-protected sulfide maintains integrity during coupling steps. Its compatibility with standard Fmoc and Boc strategies facilitates efficient sequence assembly, and the functional group tolerance supports diverse synthetic workflows in medicinal chemistry and API development.

Synthesis

Route1
- 1070-19-5
- In-stock
  
  7314-32-1
- ~81%
- In-stock
  
  60280-45-7
References
- Van Nispen; Bijl; Hendrix; Greven Recueil des Travaux Chimiques des Pays Bas, 1983 , vol. 102, # 5 p. 276 - 283
Route2
- In-stock
  
  2488-15-5
- ~%
- In-stock
  
  60280-45-7
References
- Journal of Natural Products, , vol. 76, # 4 p. 755 - 758

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 109.77
LogP 0.399
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 5

Other Classifications

Life Science Amino Acids and their Derivatives Methionine and derivatives

Building Blocks Functional Group Boc

Building Blocks Functional Group Sulfone

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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Boc-Met(O2)-OH

CAS No. 60280-45-7

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