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CS-W001157 4
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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid

  • CAS No. 1247791-23-6

  • Cat. No. CS-0375938
  • Purity≥98%
  • MDL No.MFCD06796896

*For research and further manufacturing use only, not for direct human use.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid|CS-0375938

Structure of 1247791-23-6

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General Information

  • CAS No. 1247791-23-6
  • Cat. No. CS-0375938
  • Purity ≥98%
  • MDL No. MFCD06796896
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₁NO₆S
  • Molecular Weight 403.45
  • Synonym(s) Fmoc-D-methionine sulfone
  • SMILES O=C(O)[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CCS(=O)(C)=O

Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid features a bench-stable fluorenylmethoxycarbonyl (Fmoc) protecting group and a sulfonated aliphatic side chain. This combination enables efficient incorporation into peptide synthesis workflows, offering enhanced solubility and stability during automated and manual coupling procedures.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid serves as a versatile chiral building block for peptide synthesis and medicinal chemistry applications. The fluorenylmethoxycarbonyl (Fmoc) group enables orthogonal protection of primary amines, while the methylsulfonyl moiety provides enhanced solubility and metabolic stability. This compound exhibits excellent bench stability, facilitates straightforward purification, and participates reliably in standard coupling reactions, making it well-suited for solid-phase and solution-phase peptide assembly.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   109.77
  • LogP   2.413
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   7

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