2,6-Difluorobenzene-1-sulfonyl chloride

Name: 2,6-Difluorobenzene-1-sulfonyl chloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 60230-36-6
Cat. No. CS-W007930
Purity≥98%
MDL No.MFCD00085004

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2,6-Difluorobenzene-1-sulfonyl chloride|CS-W007930

Structure of 60230-36-6

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General Information

CAS No. 60230-36-6
Cat. No. CS-W007930
Purity ≥98%
MDL No. MFCD00085004
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClF₂O₂S
Molecular Weight 212.60
Synonym(s) 2,6-Difluorobenzenesulfonyl chloride
SMILES O=S(C1=C(F)C=CC=C1F)(Cl)=O

Description

2,6-Difluorobenzene-1-sulfonyl chloride features a sulfonyl chloride group flanked by two fluorine atoms at the 2 and 6 positions, enhancing electrophilicity and directing substitution. This electron-deficient arylsulfonyl chloride enables selective coupling in synthetic routes requiring high reactivity under mild conditions.

Application

2,6-Difluorobenzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the selective introduction of sulfonamide groups under mild conditions. Its ortho-fluoro substitution enhances electrophilicity while maintaining bench stability and compatibility with diverse functional groups. The reagent facilitates efficient synthesis of sulfonamide-containing building blocks used in medicinal chemistry and agrochemical development, offering predictable reactivity and straightforward purification via crystallization or chromatography.

Synthesis

Route1
- 372-18-9
- ~%
- In-stock
  
  60230-36-6
References
- US2013/53562 A1, ; Paragraph 0073 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 1.8923
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,6-Difluorobenzene-1-sulfonyl chloride

CAS No. 60230-36-6

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