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CS-W001157 4
Total: USD 88.00

2-Chloro-5-iodonicotinic acid

  • CAS No. 59782-86-4

  • Cat. No. CS-0157380
  • Purity≥98%
  • MDL No.MFCD08276959

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-iodonicotinic acid|CS-0157380

Structure of 59782-86-4

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General Information

  • CAS No. 59782-86-4
  • Cat. No. CS-0157380
  • Purity ≥98%
  • MDL No. MFCD08276959
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClINO₂
  • Molecular Weight 283.45
  • Synonym(s) None
  • SMILES C1=C(C=NC(=C1C(=O)O)Cl)I

Description

2-Chloro-5-iodonicotinic acid is a halogenated pyridine carboxylic acid featuring strategically positioned chlorine and iodine substituents. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions, serving as a key building block for bioactive heterocycles. The carboxylic acid group facilitates conjugation and derivatization under standard conditions.

Application

2-Chloro-5-iodonicotinic acid serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its orthogonal halogenation pattern enables selective cross-coupling reactions, particularly Suzuki-Miyaura and Stille couplings, with high efficiency and excellent functional group tolerance. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.0378
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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