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Structure of 59394-28-4
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8-Chloroquinoline-2-carbaldehyde features a chlorinated quinoline core with an aldehyde functional group at the 2-position, enabling direct coupling in heterocyclic synthesis. This electron-deficient scaffold integrates readily into bioactive molecule frameworks, particularly in medicinal chemistry and ligand design. The compound exhibits enhanced reactivity due to the combined influence of the electron-withdrawing chlorine and carbonyl groups.
8-Chloroquinoline-2-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of quinoline-based scaffolds through standard coupling and functionalization reactions. Its electrophilic aldehyde group facilitates efficient imine formation and reductive amination, while the chlorine substituent supports palladium-catalyzed cross-coupling. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P264-P270-P280-P330-P501
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Lot numbers can be found on the outside label of a product: